BIO09046 2013 Upstream Bioprocessing Practical

General Details

Full Title
Upstream Bioprocessing Practical
Transcript Title
Upstream Practical
Code
BIO09046
Attendance
N/A %
Subject Area
BIO - Bio Tech/Eng/Chem
Department
ASCI - Applied Sciences
Level
09 - NFQ Level 9
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2013 - Full Academic Year 2013-14
End Term
9999 - The End of Time
Author(s)
Sharon Barrett
Programme Membership
SG_SBIOP_M09 201300 Master of Science in Biopharmaceutical Science SG_SBIOP_M09 201700 Master of Science in Biopharmaceutical Science SG_SBIOP_E09 201700 Level 9 Certificate in Biopharmaceutical Science SG_SBIOP_O09 201700 Postgraduate Diploma in Science in Biopharmaceutical Science SG_SBIOP_M09 201300 Master of Science in Biopharmaceutical Science SG_SBIOP_M09 201700 Master of Science in Biopharmaceutical Science SG_SBIOP_M09 201700 Master of Science in Biopharmaceutical Science SG_SBIPR_M09 201900 Master of Science in Biopharmaceutical Processing
Description

This module covers much of the practical knowledge, know-how and skills associated with the upstream cell-culture processing in a typical modern biopharmaceutical processing facility. The relevant learning is acquired through the completion of a sequence of laboratory-based and pilot-plant based practicals and experiments that are designed to impart the required knowledge, know-how and skills.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Demonstrate a range of practical know-how and skills associated with relevant, lab-based upstream bioprocessing equipment for the Biopharmaceutical Processing industry.

2.

Demonstrate a range of practical know-how and skills associated with relevant, pilot-plant based upstream bioprocessing equipment for the Biopharmaceutical Processing industry.

3.

Interpret and critically evaluate the data and results obtained from the various upstream processing practicals.

4.

Take responsibility for and direct the work of other individuals in a GMP- like environment.

5.

Demonstrate research skill and capabilities in the overall upstream bioprocessing area.

6.

Evaluate ongoing education and training needs in a continuous professional development environment.

7.

Demonstrate effective communication skills both orally and in writing.

Module Assessment Strategies

As this is a practical-based module attendance at the NIBRT or IT Sligo training laboratories is a requirement. A certain amount of the assessment work will take place at these locations. The remaining assessment approach for this module will be 100% Continuous Assessment with a range of assessment methods employed including some of the following: short-form assessment exams incl. MCQ’s/SAQ’s, project assignments/reports, practical/project work, essays, oral presentations, vivas etc.

Module Dependencies

Prerequisites
BIO09002 200800 FERMENTATION AND CELL CULTURE PROCESS

Indicative Syllabus

The range of lab-based practicals covered may include some or all of the following items: aseptic techniques; cell culture techniques including cell counting (both manual and automated); sub-culturing including media exchange; thawing up and freezing-down of cells; benchtop bioreactor techniques such as disassembly/reassembly of parts; bioreactor instrument calibration; preparation of bioreactor for autoclaving; inoculation and operation of bioreactor; sampling and substrate analysis.

The range of pilot-plant based practicals covered may include some or all of the following items: P+ID (Piping and Instrumentation Diagrams) analysis work on bioreactor systems; CIP cycle operation on bioreactor systems; SIP cycle operation on bioreactor systems; cell culture run on the bioreactor vessel; operation of the perfusion skid system for the bioreactor vessel; calibration of pH and DO instruments; kla measurement on the bioreactor vessel under different operating conditions; aseptic sampling from the harvest vessel using the Novaseptum system; operation of the disc-stack centrifuge separating system; P+ID analysis work on the microfiltration skid system; operation of the microfiltration system; operation of the depth filtration skid system.

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
100 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Open Book Exam End of practical assessment exams. Continuous Assessment UNKNOWN 30 % Any 1,2,3
2 Written Report Report on lab. practical work completed. Continuous Assessment UNKNOWN 20 % Any 1,2,3,4
3 Individual Project Research project report and presentation. Continuous Assessment UNKNOWN 50 % Any 3,5,6,7

Part Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Not Specified Ongoing lectures. 1 Fortnightly 0.50
Independent Learning UNKNOWN Research project report and presentation. 3 Weekly 3.00
Laboratory Practical Science Laboratory NIBRT Training Facility attendance. 16 UNKNOWN 16.00
Total Part Time Average Weekly Learner Contact Time 16.50 Hours

Module Resources

Non ISBN Literary Resources

Doran, Pauline M. 'Bioprocess Engineering Principles'. Academic Press. 1995.

Ratledge, Colin and Kristiansen Bjorn. 'Basic Biotechnology'. Cambridge Press. 2001.

Walsh, Gary. 'Biopharmaceuticals'. Wiley. 2003.

Other Resources

None

Additional Information

None