PHRM07005 2013 PHARMACEUTICAL ANALYSIS

General Details

Full Title
PHARMACEUTICAL ANALYSIS
Transcript Title
PHARMACEUTICAL ANALYSIS
Code
PHRM07005
Attendance
70 %
Subject Area
PHRM - Pharmaceutical Science
Department
LIFE - Life Sciences
Level
07 - NFQ Level 7
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2013 - Full Academic Year 2013-14
End Term
9999 - The End of Time
Author(s)
Fiona McArdle
Programme Membership
SG_SPHAR_J07 201300 Bachelor of Science in Pharmaceutical Science SG_SPHAD_B07 201800 Bachelor of Science in Pharmaceutical Science
Description

This module covers the essential aspects of separation science for pharmaceutical samples. It addresses the issues of quality within measurements and examines the various sample types encountered within the pharmaceutical industry. It also addresses aspects of sample preparation and pretreatment.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

List the intermolecular forces responsible for solubility, attraction and repulsion forces in chemical solutions.

2.

Describe two theories of band broadening in column chromatography.

3.

Explain the chemistries of some of the phases used in instrumental chromatographic techniques.

4.

Identify suitable sample preparation techniques for a variety of pharmaceutical samples.

5.

Interpret data from qualitative and quantitative chromatographic determinations.

6.

Communicate scientific data in an appropriate format.

Teaching and Learning Strategies

This module will be taught through a variety of modes including lecture, EBL and tutorial.

Module Assessment Strategies

This module will be assessed by a number of short tests during the semester and by a final examination.

Module Dependencies

Prerequisites
CHEMISTRY 1 CHEMISTRY 2 (or equivalent) ANALYTICAL TECHNIQUES
Co-requisites
None
Incompatibles
None

Indicative Syllabus

1.      Intermolecular interactions and partition coefficients.
2.      Solvent and solid phase extraction techniques.
3.      Theories of band broadening in column chromatography.
4.      Definition of terms (efficiency, capacity factor, selectivity, resolution, van Deemter)
5.      Overview of stationary and mobile phases in column chromatography.
6.      Instrumental separations, e.g. HPLC, GC, IC, GCMS.
7.      Qualitative and quantitative evaluation and interpretation of chromatographic separations.

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
40 %
End of Semester / Year Formal Exam
60 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Short questions Formative UNKNOWN - % OnGoing 1,2,3
2 Short questions Continuous Assessment UNKNOWN 20 % OnGoing 1,2,3
3 Assignment Continuous Assessment UNKNOWN 20 % Week 4 4,5,6

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Final examination Final Exam Closed Book Exam 60 % End of Term 1,2,3,4,5
             
             

Full Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Tiered Classroom Lecture 2 Weekly 2.00
Problem Based Learning Computer Laboratory Problem Based Learning 1 Weekly 1.00
Independent Learning UNKNOWN Self study 4 Weekly 4.00
Total Full Time Average Weekly Learner Contact Time 3.00 Hours

Module Resources

Non ISBN Literary Resources

Quantitative Chemical Analysis, Daniel C. Harris, 8th Edition, 2011.

Practical Laboratory Skills Training Guide: HPLC, E. Prichard, B Stuart, RSC, 2st Ed., 2009.

Chromatography: Concepts and Contrast, 2nd Edition, James Miller, Wiley-Interscience, 2009.

Chromatography and Separation Science, Satinder Ahaja, Academic Press, 1st Ed. 2002.

Pharmaceutical Analysis, 3rd Edition, David G. Watson, Churchill Livingstone, 2012.

Pharmaceutical Analysis, David C. Lee, Michael L. Webb, Wiley, 2009.

Handbook of Pharmaceutical Analysis by HPLC, Satinder Ahuja, Michael Dong, Elsevier, 2005.

 

Other Resources

British Pharmacopoeia

European Pharmacopoeia

US Pharmacopoeia

Additional Information

None