PHRM07005 2013 PHARMACEUTICAL ANALYSIS
This module covers the essential aspects of separation science for pharmaceutical samples. It addresses the issues of quality within measurements and examines the various sample types encountered within the pharmaceutical industry. It also addresses aspects of sample preparation and pretreatment.
Learning Outcomes
On completion of this module the learner will/should be able to;
List the intermolecular forces responsible for solubility, attraction and repulsion forces in chemical solutions.
Describe two theories of band broadening in column chromatography.
Explain the chemistries of some of the phases used in instrumental chromatographic techniques.
Identify suitable sample preparation techniques for a variety of pharmaceutical samples.
Interpret data from qualitative and quantitative chromatographic determinations.
Communicate scientific data in an appropriate format.
Teaching and Learning Strategies
This module will be taught through a variety of modes including lecture, EBL and tutorial.
Module Assessment Strategies
This module will be assessed by a number of short tests during the semester and by a final examination.
Module Dependencies
Indicative Syllabus
1. Intermolecular interactions and partition coefficients.
2. Solvent and solid phase extraction techniques.
3. Theories of band broadening in column chromatography.
4. Definition of terms (efficiency, capacity factor, selectivity, resolution, van Deemter)
5. Overview of stationary and mobile phases in column chromatography.
6. Instrumental separations, e.g. HPLC, GC, IC, GCMS.
7. Qualitative and quantitative evaluation and interpretation of chromatographic separations.
Coursework & Assessment Breakdown
Coursework Assessment
Title | Type | Form | Percent | Week | Learning Outcomes Assessed | |
---|---|---|---|---|---|---|
1 | Short questions | Formative | UNKNOWN | - % | OnGoing | 1,2,3 |
2 | Short questions | Continuous Assessment | UNKNOWN | 20 % | OnGoing | 1,2,3 |
3 | Assignment | Continuous Assessment | UNKNOWN | 20 % | Week 4 | 4,5,6 |
End of Semester / Year Assessment
Title | Type | Form | Percent | Week | Learning Outcomes Assessed | |
---|---|---|---|---|---|---|
1 | Final examination | Final Exam | Closed Book Exam | 60 % | End of Term | 1,2,3,4,5 |
Full Time Mode Workload
Type | Location | Description | Hours | Frequency | Avg Workload |
---|---|---|---|---|---|
Lecture | Tiered Classroom | Lecture | 2 | Weekly | 2.00 |
Problem Based Learning | Computer Laboratory | Problem Based Learning | 1 | Weekly | 1.00 |
Independent Learning | UNKNOWN | Self study | 4 | Weekly | 4.00 |
Module Resources
Quantitative Chemical Analysis, Daniel C. Harris, 8th Edition, 2011.
Practical Laboratory Skills Training Guide: HPLC, E. Prichard, B Stuart, RSC, 2st Ed., 2009.
Chromatography: Concepts and Contrast, 2nd Edition, James Miller, Wiley-Interscience, 2009.
Chromatography and Separation Science, Satinder Ahaja, Academic Press, 1st Ed. 2002.
Pharmaceutical Analysis, 3rd Edition, David G. Watson, Churchill Livingstone, 2012.
Pharmaceutical Analysis, David C. Lee, Michael L. Webb, Wiley, 2009.
Handbook of Pharmaceutical Analysis by HPLC, Satinder Ahuja, Michael Dong, Elsevier, 2005.
British Pharmacopoeia
European Pharmacopoeia
US Pharmacopoeia
None