PHRM06007 2013 APPLIED PHARMACEUTICAL SCIENCE

General Details

Full Title
APPLIED PHARMACEUTICAL SCIENCE
Transcript Title
APPLIED PHARMACEUTICAL SCIENC
Code
PHRM06007
Attendance
75 %
Subject Area
PHRM - Pharmaceutical Science
Department
ASCI - Applied Sciences
Level
06 - NFQ Level 6
Credit
15 - 15 Credits
Duration
Semester
Fee
Start Term
2013 - Full Academic Year 2013-14
End Term
9999 - The End of Time
Author(s)
John Barrett Phd., James Brennan, Carmel Moran, Declan Shelly
Programme Membership
SG_SPHAR_C06 201300 Higher Certificate in Science in Pharmaceutical Science SG_SSCIE_H08 201600 Bachelor of Science (Honours) SG_SSCIE_C06 201600 Higher Certificate in Science SG_SSCIE_H08 201700 Bachelor of Science (Honours) SG_SSCIE_C06 201700 Higher Certificate in Science
Description

This is an integrated module, which combines aspects of organic chemical synthesis, physical chemistry, analytical techniques and microbiology.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Demonstrate competence in the practical application of a range of synthetic organic chemical techniques and analytical techniques used for pharmaceutical science.

2.

Calculate chemical compositions from raw analytical data in a variety of units and evaluate the reliability of analytical data using simple statistical and quality control techniques.

3.

Record data and maintain records of synthetic and analytical work in a laboratory notebook in a format required by Good Laboratory Practice and ISO17025.

4.

Explain the kinetics of reaction rates and the factors affecting reaction rates.

5.

Write experimental reports concisely, and in proper scientific format.

6.

Understand microbial ecology and its relationship to pharmaceutical product manufacture.

7.
Understand the importance of microbiological monitoring as a regulatory and quality control requirement.

Module Dependencies

Prerequisites
None
Co-requisites
None
Incompatibles
None

Indicative Syllabus

This is an integrated course, which combines aspects of organic chemical synthesis, physical chemistry, analytical techniques and microbiology. Practical sessions will include functional group interconversions, such as,

Synthesis of a ketone

Synthesis of an alkene

Synthesis of an alcohol

Synthesis of an ester and ester hydrolysis - examination of reaction rate.

The module will combine synthetic techniques with qualitative and quantitative analysis of product. Qualitative and quantitative analysis will utilise common instrumental (infrared, refractive index, gas chromatography, atomic absorption) and non-instrumental chemical techniques.

Product analysis will also include:

Bioburden testing, endotoxin testing and sterility testing where applicable.Emphasis throughout is on data quality and developing a high standard of personal competence and confidence in a laboratory environment.

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
70 %
End of Semester / Year Formal Exam
30 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Question and Answer sessions. Laboratory workshops. Formative UNKNOWN - % OnGoing 1,2,3,4,5,6,7
2 Laboratory sessions.
Written assessments.
Multiple choice questions.
Short answer questions.
Continuous Assessment UNKNOWN 70 % OnGoing 1,2,3,4,5,6,7
             

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Written Examination. Final Exam UNKNOWN 30 % End of Term 1,2,3,4,5,6,7
             
             

Full Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Tiered Classroom Lecture 3 Weekly 3.00
Laboratory Practical Science Laboratory Laboraotory Practical 6 Weekly 6.00
Independent Learning UNKNOWN Self Study 3 Weekly 3.00
Total Full Time Average Weekly Learner Contact Time 9.00 Hours

Module Resources

Non ISBN Literary Resources

Denyer S.P.  and, Rosamund M. Baird, R.M.  Guide to Microbiological Control in Pharmaceuticals and Medical Devices (Second Edition). 2006. CRC Press.

Hewitt, W. Microbiological Assay for Pharmaceutical Analysis: A Rational Approach. 2003. Interpharm/CRC.

Harris, Daniel C. Quantitative Chemical Analysis, 7th Edition (2006), Publ. W.H Freeman and Company (1)

Moran, C., Applied Pharmaceutical Science Analytical Laboratory Manual and Theory Notes, IT Sligo.

Skoog, D.A., West, D. M., Holler F. J. (1997) 7th Edition Fundamentals of Analytical Chemistry Saunders College Publishing(1)

George W O Mc Intyre P S (1987) Infrared Spectroscopy (ACOL series), Pub. by J. Wiley &Sons.

Anderson R Sample Preparation and Pretreatment (ACOL series), Pub. by J. Wiley & Sons.

George W O McIntyre P S (1987) Infrared Spectroscopy (ACOL series, Pub. by J. Wiley & Sons.

Other Resources

None 

Additional Information

None