PHAR08001 2019 PHARMACEUTICAL PHARMACOLOGY

General Details

Full Title
PHARMACEUTICAL PHARMACOLOGY
Transcript Title
PHARMACEUTICAL PHARMACOLOGY
Code
PHAR08001
Attendance
N/A %
Subject Area
PHAR - Pharmacology
Department
LIFE - Life Sciences
Level
08 - NFQ Level 8
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2019 - Full Academic Year 2019-20
End Term
9999 - The End of Time
Author(s)
Tom Patton, Mary Garvey
Programme Membership
SG_SPHAR_H08 201900 Bachelor of Science (Honours) in Pharmaceutical Science SG_SPHAR_K08 201900 Bachelor of Science (Honours) in Science in Pharmaceutical Science
Description

This module is designed to introduce pharmaceutical pharmacology to students who are pursuing degrees scientific areas. Topics will include the basic principles of pharmacology and several major classes of therapeutic agents, with attention to their mechanisms of action by which drugs act and relates these to their overall pharmacological effects and clinical applications.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Gain a thorough understanding of Pharmacodynamics, the basic principles underlying drug action in the mammalian body and the Pharmacokinetics effect of the body on the drug molecule.

2.

Describe the endocrine, nervous and excretory systems and the mechanisms of drug interaction with these systems.

3.

Detail the MOA of Diuretics and Drugs Affecting Renal Function, Cardiovascular and Respiratory Pharmacology.

4.

Describe the key factors involved in drug-receptor interaction and intracellular signalling mechanisms.

5.

Detail the methods of Chemotherapy and modes of activity/selectivity, Structure Activity Relationship, Describe the mechanisms of transfer and of manipulation of the genetic elements involved in antibiotic resistance.

6.
Demonstrate research techniques for obtaining drug information from drug references and other sources.

Teaching and Learning Strategies

This module will be delivered full-time. This module wil include a 2 hour lecture and a 1.5 hour computer workshop session weekly augmented by independent learning and directed learning. This approach is expected to address student learning needs. moodle will be used as a repository of educational resources and as a means of assessment (quizzes).

Module Assessment Strategies

This module has a final exam worth 60% and a continuous assessment element worth 40%.

CA will consist of ongoing short answer questions and multiple choice quizzes.

Repeat Assessments

Repeat Continuous Assessment and/or Final Exam.

Module Dependencies

Prerequisites
Pharmaceutical Science Year I and II
Co-requisites
None
Incompatibles
None

Indicative Syllabus

1. Gain a thorough understanding of Pharmacodynamics, the basic principles underlying drug action in the mammalian body and the Pharmacokinetics effect of the body on the drug molecule.

  • General Principles Introduction, ADME and Definition of Terms, Pharmacokinetics, Pharmacodynamics - Relationship of Distributional Factors and Protein Binding, to Concentration of Drug at the Receptor Site, Pharmacogenetics/genomics, Principles of Drug Interactions, Development, Evaluation and Control of Drugs

2. Describe the endocrine, nervous and excretory systems and the mechanisms of drug interaction with these systems.

  • Cardiovascular and Respiratory Pharmacology. Review of Cardiovascular Physiology, Drugs Used for Cardiac and Cardiovascular Therapy. Anti-Arrhythmic Agents - Introduction to Cardiac Electrophysiology, Pharmacological Agents, Management of Acute and Chronic Heart Failure, Antihypertensive and Related medicines, AntiAnginal Drugs
  • Diuretics and Drugs Affecting Renal Function, Water, and Electrolyte Metabolism. Review of Renal Physiology/Biochemistry, Diuretics, Agents Affecting the Renal Conservation of Water.
  • Gastrointestinal Drugs. Drugs for the Treatment of Peptic Ulcer Disease, Secretory Drugs, Prokinetic Drugs, Laxative Drugs

3. Detail the MOA of Diuretics and Drugs Affecting Renal Function, Cardiovascular and Respiratory Pharmacology.

  • Endocrine Pharmacology. Hypothalamus, Anterior and Posterior Pituitary, Adrenal Cortex- Glucocorticoids/related drugs Mineralocorticoids/related drugs, Gonads, Estrogens/Progestins/related drugs, Androgens/related drugs, Thyroid, mechanisms by which thyroid hormones regulate cellular function, Pancreas/related Drugs, insulin secretion mechanism.

4. Describe the key factors involved in drug-receptor interaction and intracellular signalling mechanisms

  • Introduction to the autonomic nervous system, Cholinergic neurotransmission and muscarinic agonists, Anticholinesterase, Antagonists at muscarinic receptor sites, , Drugs acting at autonomic ganglia, Antagonists at nicotinic receptor sites in the skeletal neuromuscular junction, Sympathetic neurotransmission, and the adrenal medulla, Indirectly acting sympathomimetic agents,
  • Drugs Acting on the Central Nervous System. Neurotransmitters, Neuromodulators, and Receptors, General Anaesthetics, Local Anaesthetics, Opioid Analgesics, Agonist antagonists, medicines Used in the Treatment of Motor Disorders, Antiepileptics

5. Detail the methods of Chemotherapy and modes of activity/selectivity, Structure Activity Relationship, Describe the mechanisms of transfer and of manipulation of the genetic elements involved in antibiotic resistance.

  • Chemotherapy. Introduction of chemotherapy, Sulfonamides and DNA gyrase inhibitors, Inhibitors of Cell Wall Synthesis, Inhibitors of protein synthesis, Antimycobacterial Drugs, Antifungal Agents, Antiviral Drugs, Antiparasitic Drugs, Anticancer Drugs, immunomodulators.

6. Demonstrate research techniques for obtaining drug information from drug references and other sources

  • Clinical Trials

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
40 %
End of Semester / Year Formal Exam
60 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Short Answer Questions
Multiple Choice Questions Assignment
Continuous Assessment Assessment 40 % OnGoing 1,6
             
             

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Final Written Exam Final Exam Closed Book Exam 60 % End of Term 1,2,3,4,5
             
             

Full Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Not Specified Lecture 2 Weekly 2.00
Problem Based Learning Computer Laboratory Problem Based Learning 2 Weekly 2.00
Independent Learning UNKNOWN Self Study 4 Weekly 4.00
Total Full Time Average Weekly Learner Contact Time 4.00 Hours

Required & Recommended Book List

Required Reading
2019-01-11 Rang and Dale's Pharmacology Elsevier
ISBN 0702074489 ISBN-13 9780702074486

Comprehensive yet easy to use, Rang and Dale's Pharmacology has been providing core basic and clinical science information to students and healthcare practitioners worldwide for more than 25 years. The fully revised 9th Edition keeps you up to date with all that's new in the field, including new and emerging drugs and recent studies. From cover to cover, you'll progressively increase your knowledge of all relevant aspects of pharmacology, from a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs. Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more. Includes access to unique features online, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment. Features a color-coded layout for faster navigation and cross-referencing. Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references - including 68 bonus dissection videos - from the book on a variety of devices.

Required Reading
2014 The Top 100 Drugs Churchill Livingstone
ISBN 0702055166 ISBN-13 9780702055164

Prescribing for the first time is a nerve-wracking experience. Of all the tasks performed by new doctors, it is probably the one with greatest direct impact on the wellbeing of patients. Safe and effective practice rests on a good understanding of both clinical pharmacology and practical prescribing. Acquiring this is not easy, particularly when faced with reams of information about hundreds of unfamiliar drugs, often presented in a way that appears detached from clinical reality. This book is your starting point. It is a direct response to requests from students for a compendium of the 100 most important drugs in the NHS. Key information about the clinical pharmacology and practical prescribing of each drug is presented side-by-side, allowing you to direct your attention as appropriate for your stage of training. Drugs can be accessed alphabetically when you need quick information on the wards and by organ system or clinical indication when you are at your desk. Research led by Professor Emma Baker has identified the 'top 100 drugs' by their importance and prescribing frequency. She has shown that the list changes little over time, making it a stable resource upon which to base learning. "A great practical resource for those new to prescribing the text is aimed at those new to independent prescribing, and for that group I would consider The Top 100 Drugs to be an excellent publication" Reviewed by: Emma Watts on behalf of (journal) Pulse Date: April 2015 The top 100 drugs and the five most important intravenous fluids are presented using a clear, consistent layout across double-page spreads. Drugs are arranged alphabetically and also listed by organ system and clinical indication, providing multiple pathways into the information. Clinical pharmacology is discussed under the headings: common indications; mechanisms of action; important adverse effects; warnings; and important interactions. Practical prescribing is discussed under the headings: prescription; administration; communication; monitoring; and cost. A clinical tip is presented for every drug. Single-best-answer questions are provided for self-assessment and to show how information from several drugs may be integrated.

Required Reading
2017-10-30 Pharmacology for Chemists Royal Society of Chemistry
ISBN 9781782621423 ISBN-13 1782621423

Module Resources

Non ISBN Literary Resources
  • Rang & Dale's Pharmacology, 9 Edition 2019 by James M. Ritter DPhil FRCP FBPharmacolS FMedSci (Author), Rod J. Flower PhD DSc FBPharmacolS FMedSci FRS (Author), Graeme Henderson BSc PhD FBPharmacolS FSB (Author), Yoon Kong Loke MB BS MRCP MD (Author), David MacEwan (Author), Humphrey P. Rang MB BS MA DPhil Hon FBPharmacolS FMedSci FRS (Author)
  • Basic Concepts in Pharmacology by Janet L. Stringer. Sep 26, 2005, MCGRAW-HILL'S.
  • Introduction to Pharmacology by Mannfred A. Hollinger. Nov 28, 2002.
  • Pharmacology for Chemists: Drug Discovery in Context Hardcover – 2017 by Raymond Hill (Author, Editor), Terry Kenakin (Editor), Tom Blackburn(Editor)
  • Goodman and Gilman's The Pharmacologic Basis of Therapeutics, McGraw Hill, 11th ed., 2006.

 

Journal Resources

European Journal of Pharmacology

https://www.journals.elsevier.com/european-journal-of-pharmacology/

 

Journal of Pharmacology and Experimental Therapeutics

http://jpet.aspetjournals.org/

Other Resources

PCCAL Pharmacology Computer Simulation - PRACTICAL PBL  SECTION.

Additional Information

None