CHEM08008 2019 FORENSIC CHEMICAL ANALYSIS
This module covers advanced topics in forensic analysis. spectroscopy and atomic spectrometry, chromatography, electroanalytical and sample preparation for these techniques. In involves collection, storage, preparation & pretreatments of forensic samples. This module covers the wide range of advanced instrument currently available and also addresses troubleshooting and problem solving with advanced instrumentation. This module also covers evaluation of chromatographic data and interpretation of spectra as well as instrument characteristics.
On completion of this module the learner will/should be able to;
Evaluate appropriate sample preparation techniques for chromatographic and spectrometric analysis.
Interpret chromatographic and spectrometric data and investigate troubleshooting and problem solving strategies for chromatographic and other analytical systems.
Evaluate validation procedures for chromatographic methods for forensic and clinical samples.
Examine a range of electroanalytical methodologies and assess their role in forensic applications.
Assess and compare analytical features of advanced analytical techniques such as the detection capability and interferences of atomic spectrometry techniques
Teaching and Learning Strategies
This module will be taught through a range of lecturers, workshops and presentations. The students will learn through the use of on line materials, lecture notes and research papers.
This module will be delivered fulltime (or part-time for online modules). This will include lectures, problem based learning (PBL) interactive workshops(including trouble shooting of analytical instruments) , practical demonstrations and presentations augmented by independent learning and directed learning. This approach is expected to address student learning needs. Moodle will be used as a repository of educational resources and as a means of assessment (e.g. quizzes, uploading assignments and journal references). Self-assessment tests and other forms of formative assessment are provided to students to check their own progress towards achieving the learning outcomes of the module and to motivate learning.
Module Assessment Strategies
This module is 50% Continuous Assessment and 50 % Final exam. The continuous assessment will include the following elements: formative assessment through preparation of assignments for discussion at interactive workshops; written assessment via short question tests ; regular workshop assignments ; Data analysis, literature interpretation, spectral interpretation and problem solving of advance instrumentation.
The student must reach an assigned gate (30%) in the final exam and achieve 40% overall to pass the subject.
Repeat continuous assessment
1. Sample preparation techniques for trace organic determinations by chromatographic analysis (SPE, solvent extraction, SCF extraction, derivatisation)
2. Sample preparation for trace metal analysis and for molecular spectroscopy
3. Interpretation of chromatograms and spectra (qualitative & quantitative) and integration parameters.
4. Chromatographic columns functionalities and detection systems and trouble shooting.
5. Hyphenated techniques (GCMS, LCMS, ICPMS, ICPOES, MS/MS)
6. Electroanalytical techniques (voltammetry, amperometry, polarography)
7. NMR, FTIR, Raman spectroscopy
8. Novel forensic analytical techniques
Coursework & Assessment Breakdown
|Title||Type||Form||Percent||Week||Learning Outcomes Assessed|
|1||Short Questions, Spectral Interpretation, Calculations, Data Analysis.||Formative||Assessment||- %||OnGoing||1,2,5|
|2||Data & Literature evaluation, problem solving||Continuous Assessment||Assessment||25 %||OnGoing||1,2,3|
|3||Spectral Interpretation, Short Questions.||Continuous Assessment||UNKNOWN||25 %||OnGoing||1,2,3,5|
End of Semester / Year Assessment
|Title||Type||Form||Percent||Week||Learning Outcomes Assessed|
|1||Data Evaluation, Questions.||Final Exam||UNKNOWN||50 %||End of Term||1,2,3,4,5|
Full Time Mode Workload
|Problem Based Learning||Computer Laboratory||PBL||2||Weekly||2.00|
|Independent Learning||Library||Self Study||3||Weekly||3.00|
Ardrey, R. E., Liquid Chromatography-Mass Spectrometry: An Introduction, Wiley, 2003.
Boyd, R. K., Basic, C. and Bethem, R. A. (2008) Trace quantitative chemical analysis by mass spectrometry, Chichester: Wiley.
Broekaert, J. A. C. (2002) Analytical atomic spectrometry with flames and plasmas, Weinheim: Wiley-VCH.
Cole, M. D. (2003) The analysis of controlled substances, New York: Wiley.
Dean, J. R., Ando, D. J. and Metcalfe, E. (1997) Atomic absorption and plasma spectroscopy, Chichester: Published on behalf of ACOL (University of Greenwich) by J. Wiley.
Downard, K. and Royal Society of, C. (2004) Mass spectrometry: a foundation course, Cambridge: Royal Society of Chemistry.
Ebdon, L. and Evans, E. H. (1998) An introduction to analytical atomic spectrometry, Chichester: John Wiley.
Hansen, S., Pedersen-Bjergaard, S. and Rasmussen, K. (2012) Introduction to pharmaceutical chemical analysis, Chichester, West Sussex: John Wiley & Sons Inc.
Haswell, S. J. (1991) Atomic absorption spectrometry: theory, design, and applications, Amsterdam: Elsevier.
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Hill, S. J. (2007) Inductively coupled plasma spectrometry and its applications, Oxford: Blackwell Pub.
Jickells, S. and Negrusz, A. P. D. (2008) Clarke's analytical forensic toxicology, Chicago: Pharmaceutical Press.
Kurfürst, U. (1998) Solid sample analysis: direct and slurry sampling using GF-AAS and ETV-ICP, New York: Springer.
Metcalfe, E. and Prichard, F. E. (1987) Atomic absorption and emission spectroscopy, Chichester: Published on behalf of ACOL, by J. Wiley.
Pretsch, E., Bühlmann, P. and Badertscher, M. (2009) Structure determination of organic compounds: tables of spectral data, Berlin: Springer.
Skoog, D.A., West, D. M., Holler F. J.(1997) 7th Edition Fundamentals of Analytical Chemistry Saunders College Publishing
Stuart, B. (2004) Infrared spectroscopy: fundamentals and applications, Chichester: John Wiley & Sons, Ltd.
Stuart, B. and Ando, D. J. (1996) Modern infrared spectroscopy, New York: Published on behalf of ACOL (University of Greenwich) by Wiley.
United States. Federal Bureau of, I. (2008) FBI handbook of crime scene forensics, New York: Skyhorse Pub.
Whittaker, D. (2000) Interpreting organic spectra, Cambridge, UK: Royal Society of Chemistry.
Quantitative Chemical Analysis, Daniel C. Harris, 8th Edition, 2011.
Practical Laboratory Skills Training Guide: HPLC, E. Prichard, B Stuart, RSC, 1st Ed., 2003.
Chromatography: Concepts and Contrast, 2ed. James Miller, Wiley, 2009.
Chromatography and Separation Science, Satinder Ahaja, Academic Press, 1st Ed. 2002.
Basic Gas Chromatography, 2ed., Harold M. Miller, James M. Miller, Willey-Interscience, 2009.
Gas Chromatography, 2ed., Ian A. Fowlis, Wiley India Pvt Ltd, 2008.
Practical High Performance Liquid Chromatography, Veronica R. Meyer, John Wiley & Sons, 2010.
Handbook of Forensic Drug Analysis, Fred Smith, Jay A. Siegel, Academic Press, 2004.
Introduction to Modern Liquid Chromatography, 3rd Ed. Lloyd R. Snyder, Joseph J. Kirkland, John W. Dolan, Wiley, 2009.
Fundamentals of Analytical Toxicology, Robert J Flanagan, Andrew Taylor, Ian D. Watson, Robin Whelpton, Wiley, 2007.
Forensic Applications of High Performance Liquid Chromatography, Shirley Bayne, Michelle Carlin, CRC Press, 2010.
Gas Chromatography in Forensic Science, Ed. Ian Tebbett, CRC Press, 1992.
Forensic Applications of Gas Chromatography, Michelle Groves carlin, John Richard Dean, CRC Press, 2013.
Electroanalytical Methods, Fritz Scholz, Springer, 2002.
Fundamentals of Electro-Analytical Chemistry, Paul M.S. Monk, John Wiley & Sons, 2008.
Electroanalytical Chemistry, Allen J. Bard, Cynthia G. Zoski, CRC Press, 2011.
Electroanalytical Chemistry Research Trends, Kenta Hayashi, Nova Science Publishers, 2008.
Understanding Voltammetry, 2ed., Richard G. Compton, Imperial College Press, 2011.
Clinical Chemistry & Molecular Diagnostics, 5th Ed., Carl A. Burtis, Edward R. Ashwood, David E. Bruns, Elsevier, 2012.
Provided on Moodle
Modern Chemical Techniques, RSC, 1995.
More provided on Moodle
Provided on Moodle