CHEM07002 2013 PHARMACEUTICAL CHEMISTRY

General Details

Full Title
PHARMACEUTICAL CHEMISTRY
Transcript Title
PHARMACEUTICAL CHEMISTRY
Code
CHEM07002
Attendance
N/A %
Subject Area
CHEM - Chemistry
Department
LIFE - Life Sciences
Level
07 - NFQ Level 7
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2013 - Full Academic Year 2013-14
End Term
2019 - Full Academic Year 2019-20
Author(s)
Aodhmar Cadogan, Declan Shelly
Programme Membership
SG_SPHAR_J07 201300 Bachelor of Science in Pharmaceutical Science SG_JSCIE_X06 201400 Certificate SG_SPHAD_B07 201800 Bachelor of Science in Pharmaceutical Science
Description

This module aims to provide the student with an understanding of the chemistry behind (i) the structure of some of the key groups of relevent biochemical and chemical molecules and (ii) the intermolecular and interfacial forces acting between and around chemical molecules giving rise to their characteristic properties.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Evaluate the importance of stereochemistry in pharmaceutical compounds

2.

Distinguish between the different structural representations of the simple carbohydrates and recognise the importance of ribose and deoxyribose.

3.

Recognise and compare examples of Lipids, Fats and Fatty Acids

4.

Recognise the structural relationships of some simple steriods.

5.

Evaluate information related to interfacial activity (e.g surface tension, surface energy, contact angles, adsorption etc) of materials to predict behaviour (e.g Wetting, Spreading, Capillarity, surface area etc) in a pharmaceutical system.

6.

Discuss the role of surface active agents in pharmaceutical formulation.

7.

Illustrate the surface forces which affect the behaviour of solids in a gas / solid system and type of isotherms.

8.

Apply numerical skills to the calculation of fundamental properties of pharmaceutical compounds

Module Assessment Strategies

Students will be assessed using a blend of essay / short answer questions, reinforced with a final written examination.

Module Dependencies

Prerequisites
None Organic Chemistry
Co-requisites
None
Incompatibles
None

Indicative Syllabus

Stereochemistry - optical activity, specific rotation, chirality, enantiomerism, configuration of stereoisomers; rules for the specification of R & S configuration of optically active compounds; racemic modifications; diastereoisomers and meso compounds.

Antibiotics - sulphonamides, b-lactam antibiotics: penicillins and cephalosporins.

Distinguish between the different structural representations of some simple carbohydrates and recognise the importance of ribose and deoxyribose.

Understand the structure and nomenclature of a variety of Lipids, Fats and Fatty Acids.

Recognise the structural relationships of some simple steriods.

Interfacial phenomena, surface tension, spreading coefficients, capillary action, contact angles.

Classification of Surface active agents, behaviour of soluble and insoluble surfactants, surface excess concentration, LB films,  and their pharmaceutical applications.

Gas Soild Adsorption characteristcs, adsorption isotherms.

Fundamental chemical properties pH, pKa, LogP and relationship to solubility and sample preparation.

Kinetics of product stability, Zero, first , second order kinetics.

 

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
40 %
End of Semester / Year Formal Exam
60 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Question and Answer sessions. Formative UNKNOWN - % OnGoing 1,2,3,4,5,6,7,8
2 Written assessment -
Multiple choice questions.
Short answer questions
Continuous Assessment UNKNOWN 40 % OnGoing 1,2,3,4,5,6,7,8
             

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Written examination. Final Exam UNKNOWN 60 % End of Term 1,2,3,4,5,6,7,8
             
             

Full Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Tiered Classroom Lecture 3 Weekly 3.00
Independent Learning UNKNOWN Self Study 4 Weekly 4.00
Total Full Time Average Weekly Learner Contact Time 3.00 Hours

Module Resources

Non ISBN Literary Resources

Pharmaceutics: The design and manufacture of medicines, 3rd Edition, Micahel E. Aulton, Churchhil Livingstone Elsiever, 2007.

An Introduction to Medicinal Chemistry, 4th Edition, Graham L. Patrick, Oxford University Press, 2009

Introduction to Pharmaceutical Chemical Analysis, Steen Honore Hansen, Stig Pedersen-Bjergaard, Knut Einar Rasmussen, John Wiley and Sons, 2012

Interfacial Science, An introduction, G.T. Barnes, I.R. Gentle, Oxford University Press, 2005

Other Resources

Remingtons Pharmaceutical Science

Pharmaceutical Codex

Additional Information

None