CHEM06047 2019 PHARMACEUTICAL ANALYTICAL METHODS

General Details

Full Title
PHARMACEUTICAL ANALYTICAL METHODS
Transcript Title
PHARMACEUTICAL ANALYTICAL METH
Code
CHEM06047
Attendance
75 %
Subject Area
CHEM - Chemistry
Department
LIFE - Life Sciences
Level
06 - NFQ Level 6
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2019 - Full Academic Year 2019-20
End Term
9999 - The End of Time
Author(s)
Fiona McArdle, Geraldine Duignan, Carmel Moran, Tom Patton
Programme Membership
SG_SPHAR_B07 201900 Bachelor of Science in Pharmaceutical Science SG_SPHAR_H08 201900 Bachelor of Science (Honours) in Pharmaceutical Science SG_SPHAR_C06 202100 Higher Certificate in Science in Pharmaceutical Science
Description

Introductory analytical techniques building on chemistry 1 and chemistry 2. The course introduces the student to fundamental chemical analytical techniques with a focus on chemical structures, concentration terms, classical and instrumental methods of determining qualitative and quantitative data. This module covers volumetric analysis including the application of primary and secondary standards. The module provides an introduction to instrumental techniques, such as, infrared spectroscopy, ultraviolet visible spectroscopy, atomic spectrometry, electroanalytical and chromatography.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Explain the purpose of most common analytical tests and describe fundamental strategies for the performance of classical and instrumental chemical analysis.

2.

Explain the fundamental principles of a range of instrumental and classical methods of analysis.

3.

Calculate chemical compositions from raw instrumental and non‑instrumental analytical data and express chemical compositions in a range of concentration units.

4.

Interpret qualitative data and ascertain chemical structures from analytical measurements.

5.

Evaluate the reliability of analytical data using simple statistical and quality control techniques.

Teaching and Learning Strategies

This module will be delivered full time. This will include lectures, workshops, tutorials and laboratory practicals.  The students will learn through engagement with the class materials / resources indicated in reading lists and through the use of multimedia tools including moodle, internet sites and podcasts.

Module Assessment Strategies

This module is 65% continuous assessment (50% practical and 15% continuous assessment theory) and 35% final examination.

Practical skills, report writing and data evaluation will be assessed fortnightly.

Short question tests will be assigned every three weeks. Half of these will be formative and half summative.

The students must react an assigned gate (30%) in the final examination and achieve 40% overall to pass the module.

 

Repeat Assessments

Repeat continuous assessment and / or final examination.

Module Dependencies

Prerequisites
CHEM06034 201300 CHEMISTRY 1 CHEM06035 201900 CHEMISTRY 2

Indicative Syllabus

Explain the purpose of most common analytical tests and describe fundamental strategies for the performance of classical and instrumental chemical analysis.

  • Fundamental steps of a chemical analysis and analytical methodology: Basic analytical GLP. Overview of chemicals, reagents and apparatus used in analytical chemistry.

Explain the fundamental principles of a range of instrumental and classical methods of analysis.

  • Wet chemical methods of analysis: Titrimetric and gravimetric calculations.
  • Spectrochemical methods: Overview of UV/Vis, IR, FAAS, GFAAS
  • Electroanalytical methods: Overview of potentiometry, conductivity, voltammetry & amperometry
  • Chromatographic methods: Overview of HPLC & GC and description of detectors for each.

Evaluate the reliability of analytical data using simple statistical and quality control techniques.

  • Statistical treatment of analytical data and aspects of quality assurance: Introduction to sampling for chemical analysis: Collection, representative samples, contamination, replicates, dissolution, digestion, extraction, etc.

Calculate chemical compositions from raw instrumental and non‑instrumental analytical data and express chemical compositions in a range of concentration units.

  • Data recording, effective use of laboratory notebook, management and presentation of analytical information. Methods for expressing concentrations: Volumetric and gravimetric calculations.

Interpret qualitative data and ascertain chemical structures from analytical measurements.

  • Instrumental analysis methodology: Instrument calibration, quantitation using single and multiple external standards. Internal standard and standard addition techniques.
  • Intrepretation of spectral data from FTIR and UV/Vis instrumentation.

 

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
65 %
End of Semester / Year Formal Exam
35 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Practicals Continuous Assessment Practical Evaluation 50 % OnGoing 1,2,3,4,5
2 Short Questions Continuous Assessment Assessment 15 % OnGoing 1,2,3,4,5
             

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Examination Final Exam Closed Book Exam 35 % End of Semester 1,2,3
             
             

Full Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Tiered Classroom Lecture 1 Weekly 1.00
Workshop Flat Classroom Workshop / Tutorial 1 Weekly 1.00
Laboratory Practical Science Laboratory Laboratory Experiments 2 Weekly 2.00
Total Full Time Average Weekly Learner Contact Time 4.00 Hours

Required & Recommended Book List

Recommended Reading
2015-05-29 Quantitative Chemical Analysis WH Freeman
ISBN 131915414X ISBN-13 9781319154141

The gold standard in analytical chemistry, Dan Harris Quantitative Chemical Analysis provides a sound physical understanding of the principles of analytical chemistry and their applications in the disciplines. Dan Harris presents the subject in a rigorous, readable and interesting manner, lucid enough for non-chemistry majors but containing the depth required by advanced undergraduates. For the first time since the book was published in 1978, Harris has worked with a new contributing author, Professor Chuck Lucy of the University of Alberta. Lucy shares his expertise and teaching experience in Chapters 23-26 on chromatography and capillary electrophoresis.

Recommended Reading
2016-07-26 Pharmaceutical Analysis Elsevier
ISBN 0702069892 ISBN-13 9780702069895

Pharmaceutical analysis forms a core part of any pharmacy programme, as well as being essential for pharmacology and medicinal chemistry courses. Pharmaceutical analysis determines the purity, concentration, active compounds, shelf life, rate of absorption in the body, identity, stability, rate of release etc. of a drug. Testing a pharmaceutical product involves a variety of analyses, and the analytical processes described in this book are used in industries as diverse as food, beverages, cosmetics, detergents, metals, paints, water, agrochemicals, biotechnological products and pharmaceuticals. The mathematics involved is notoriously difficult, but this much-praised textbook, now revised and updated for its fourth edition, guides a student through the complexities with clear writing and the author's expertise from many years' teaching pharmacy students. There is continuous learning reinforcement throughout the book by way of worked calculation examples and self-assessment test questions. Worked calculation examples Self-assessment Additional problems (self tests) Practical boxes Key points boxes New chapter on electrochemical biosensors. New chapter on the quality control of biotechnologically produced drugs. Extended chapter on molecular emission spectroscopy. Now on StudentConsult. ~

Module Resources

Non ISBN Literary Resources

Skoog, D.A., West, D. M., Holler F. J.(2013) 9th Edition Fundamentals of Analytical Chemistry, Cengage Learning

Wiley, Linsey; Chromatographic methods (ACOL Series), 1992, Wiley

Metcalfe E (1987) Atomic Absorption and Emission Spectroscopy (ACOL series) Wiley &Sons.

Thomas M J K Ando D J (Editor) (1997) Visible and Ultraviolet Spectroscopy (ACOL series) Wiley & Sons.

George W O Mc Intyre P S (1987) Infrared Spectroscopy (ACOL series), Wiley &Sons.

Anderson R Sample Preparation and Pretreatment (ACOL series), Wiley & Sons.

Thomas M J K Ando D J (Editor) (1997) Visible and Ultraviolet Spectroscopy (ACOL series), Wiley & Sons.

George W O McIntyre P S (1987) Infrared Spectroscopy (ACOL series, Wiley & Sons.  

Journal Resources

None

URL Resources

http://rsc.org/

http://chem1.com/acad/webtext/elchem/indexhtml

http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/Spectrpy/spectro.htm#contnt

http://www2.fiu.edu/~almirall/chm3120.htm

Other Resources

None

Additional Information

None