BIOC09001 2022 Clinical Biochemistry

General Details

Full Title
Clinical Biochemistry
Transcript Title
Clinical Biochemistry
N/A %
Subject Area
BIOC - Biochemistry
HEAL - Health & Nutritional Sciences
09 - NFQ Level 9
05 - 05 Credits
Start Term
2022 - Full Academic Year 2022-23
End Term
9999 - The End of Time
Thomas Smyth, James Murphy
Programme Membership
SG_SCLIN_Q09 202200 Master of Science in Clinical Measurement Physiology

The principles and processes of Biochemistry relating to the prevention, diagnosis and treatment of common human medical conditions, disorders and diseases. Understand Vascular, Respiratory, Cardiovascular, Gastrointestinal and Neuro physiology and  pathophysiology of the human body. Understand the biochemical foundation to clinical parameters in medical diagnostics, treatment and patient evaluation. Interpretation of medical laboratory tests and data to diagnose and manage common conditions and disorders. 

Learning Outcomes

On completion of this module the learner will/should be able to;


Identify appropriate medical tests; present and interpret data correctly


Summarise the physiology and pathophysiology of the human body for a range of common conditions


Explain the Biochemical principles in a range of preventative, diagnostic and treatment strategies and modalities


Evaluate biochemical parameters related to a range of medical diagnostics and testing

Teaching and Learning Strategies

Lectures will expose learners to key concepts supported by laboratory-based practicals. 

The VLE will support the module as a repository for learning material but also providing opportunities for self-directed learning through the provision of short formative assessment quizzes and activities including case study work. Module materials embrace the principles of a Universal Design for Learning approach. 

Students will be expected to actively engage with reading material and self-directed learning activities to promote integration of prior knowledge and assimilation of new specialist knowledge. 

A variety of methods of instruction such as discussion, group work, interactive exercises, use of online resources and/or use of audio/visual material will be provided. Core skills will be embedded into all modules to ensure all students have an equal opportunity to succeed. This may include academic writing, oral presentations, reading techniques or research abilities.

Module Assessment Strategies

This module will be assessed by 50% Continuous assessment which will be ongoing throughout the semester and 50% final exams. CA will be designed using data to replicate cases studies of relevance to the clinical measurement physiology field.


Repeat Assessments

Repeat CA will be issued for students needing repeat assessment.

Indicative Syllabus

  • The physiology of muscle contraction and (ir)regular lipid transport.
  • The biochemistry of epilepsy and other neurological disorders and neuromodulation treatment strategies
  • Understanding common GI disorders such as reflux disorders, Raynaud’s Disease  and others causing Non-cardiac chest pain
  • Biochemistry of cardiac excitation and contraction and biomarkers of cardiac disease
  • Biochemistry of blood pressure control and treatment
  • Biochemistry of congestive heart failure and treatment
  • Biochemistry of atherosclerotic disease and treatment
  • The biochemical basis for the detection, treatment and prevention of common conditions of Vascular; Respiratory; Cardiovascular; Gastrointestinal and Neurological origin
  • The genetic basis for cause of and predisposition for conditions and the detection of same using molecular biology
  • Recording and interpretation of Medical Biochemistry test data

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
50 %
End of Semester / Year Formal Exam
50 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Case Studies Continuous Assessment Written Report 50 % OnGoing 1,3,4

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 End of Semester Exam Final Exam Closed Book Exam 50 % End of Semester 2,3,4

Online Learning Mode Workload

Type Location Description Hours Frequency Avg Workload
Online Lecture Online Lecture 1 Weekly 1.00
Directed Learning Online Case Studies 1 Weekly 1.00
Independent Learning Online Independent Study 5 Weekly 5.00
Total Online Learning Average Weekly Learner Contact Time 2.00 Hours

Required & Recommended Book List

Required Reading
2018-01-23 Voet's Principles of Biochemistry Global Edition
ISBN 1119451663 ISBN-13 9781119451662

Voets Principles of Biochemistry, Global Edition addresses the enormous advances in biochemistry, particularly in the areas of structural biology and bioinformatics. It provides a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. New information related to advances in biochemistry and experimental approaches for studying complex systems are introduced. Notes on a variety of human diseases and pharmacological effectors have been expanded to reflect recent research findings. While continuing in its tradition of presenting complete and balanced coverage, this Global Edition includes new pedagogy and enhanced visuals that provide a clear pathway for student learning.

Required Reading
2016-11-24 Clinical Biochemistry Oxford University Press
ISBN 9780199674442 ISBN-13 0199674442

Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, andresearch into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analyticalapproaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science.Clinical Biochemistry provides a clear and comprehensive introduction to the biochemical basis of disease processes, and how these diseases can be investigated in the biomedical laboratory. New clinical case studies have been added to the second edition, to further emphasize the link between theoryand practice and help engage students with the subject.

Required Reading
2010-01-19 Textbook of Biochemistry with Clinical Correlations Wiley-Liss
ISBN 0470281731 ISBN-13 9780470281734

A comprehensive and fully updated edition filled with over 250 clinical correlations This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this seventh edition is an indispensable tool for students and professionals in the medical or health sciences.

Module Resources

Non ISBN Literary Resources
Journal Resources

Journal of Biomedical Science

European Journal of Clinical Investigation

Critical Reviews in Clinical Laboratory Sciences

URL Resources
Other Resources
Additional Information