BIO09029 2019 BIOPHARMA DISCOVERY AND DEVELOPMENT
The Biopharmaceutical Drug Discovery and Development module aims to provide students with an understanding of the stages involved in the drug discovery and development process. The module will explain the rationale behind choosing targets for drug development such as disease targets, genetic abnormalities and functional genomics and proteomics. The module also looks at the type of drug targets which are used in drug discovery and development. The expression vectors used and the regulation of exogenous gene expression in cell lines will be examined Once a target is identified, methods of validating and assaying the effectiveness of the drug and target are covered. Screening processes and regimes for potential drugs are explained and described. This module will also describe lead optimization issues involved in the drug development process. Drug development processes and production considerations leading to and including clinical drug trials are also considered in this module.
On completion of this module the learner will/should be able to;
Explain methods of drug target discovery such as disease genes and functional genomics.
Identify and describe the types of targets which are used in the biopharmaceutical sector including receptors, proteins, enzymes and nucleic acid targets.
Describe and evaluate the methods used to validate a possible drug target.
Identify and describe cell models for expression of exogenous gene products.
Explain the process of exogenous gene expression and regulation in model cell system.
Identify effective methods to quantitate and assay for drug activity.
Review and evaluate methods of screening for drugs and drug activity.
Describe and evaluate the steps required to optimize drugs for pharmacokinetics, toxicity, formulation and delivery.
Recognise and analyse the steps required to take a drug to development phase and clinical trials.
Teaching and Learning Strategies
Module Assessment Strategies
as per Q manual
Rational and Irrational drug design
Gene Delivery and expression system choice
Confirmation of expression
Analysis of functional properties
Coursework & Assessment Breakdown
|Title||Type||Form||Percent||Week||Learning Outcomes Assessed|
|1||The assessment approach for this module will be 100% Continuous Assessment with a range of assessment methods employed including some of the following: short-form assessment exams incl. MCQs, project assignments, practical work, essays, oral presentations, vivas etc.||Continuous Assessment||UNKNOWN||100 %||OnGoing||1,2,3,4,5,6,7,8,9|
Part Time Mode Workload
|Independent Learning||UNKNOWN||Self Study||7||Weekly||7.00|
Rodney, J.Y., Biotechnology and biopharmaceuticals: Transforming Genes into Drugs, Wiley-Liss, 2003
Brown, T.A., Gene Cloning and DNA Analysis. An Introduction., Oxford Blackwell, 2006
Rick, N.G., Drugs: From Discovery to Approval, Wiley-Liss, 2004
as per moodle resources
as per moodle resources
Cloud Based Educational Games (CBEG)