BIO09029 2019 BIOPHARMA DISCOVERY AND DEVELOPMENT

General Details

Full Title
BIOPHARMA DISCOVERY AND DEVELOPMENT
Transcript Title
BIOPHARMA DISCOVERY AND DEVELO
Code
BIO09029
Attendance
N/A %
Subject Area
BIO - Bio Tech/Eng/Chem
Department
LIFE - Life Sciences
Level
09 - NFQ Level 9
Credit
05 - 05 Credits
Duration
Stage
Fee
Start Term
2019 - Full Academic Year 2019-20
End Term
9999 - The End of Time
Author(s)
Mary Butler, Tony McCabe, Sharon Barrett
Programme Membership
SG_SBIOP_M09 201900 Master of Science in Biopharmaceutical Science SG_SBIOP_O09 201900 Postgraduate Diploma in Science in Science in Biopharmaceutical Science
Description

The Biopharmaceutical Drug Discovery and Development module aims to provide students with an understanding of the stages involved in the drug discovery and development process. The module will explain the rationale behind choosing targets for drug development such as disease targets, genetic abnormalities and functional genomics and proteomics. The module also looks at the type of drug targets which are used in drug discovery and development. The expression vectors used and the regulation of exogenous gene expression in cell lines will be examined Once a target is identified, methods of validating and assaying the effectiveness of the drug and target are covered. Screening processes and regimes for potential drugs are explained and described. This module will also describe lead optimization issues involved in the drug development process. Drug development processes and production considerations leading to and including clinical drug trials are also considered in this module.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Explain methods of drug target discovery such as disease genes and functional genomics.

2.

Identify and describe the types of targets which are used in the biopharmaceutical sector including receptors, proteins, enzymes and nucleic acid targets.

3.

Describe and evaluate the methods used to validate a possible drug target.

4.

Identify and describe cell models for expression of exogenous gene products.

5.

Explain the process of exogenous gene expression and regulation in model cell system.

6.

Identify effective methods to quantitate and assay for drug activity.

7.

Review and evaluate methods of screening for drugs and drug activity.

8.

Describe and evaluate the steps required to optimize drugs for pharmacokinetics, toxicity, formulation and delivery.

9.

Recognise and analyse the steps required to take a drug to development phase and clinical trials.

Teaching and Learning Strategies

100% CA

Module Assessment Strategies

100% CA

Repeat Assessments

as  per Q manual

Indicative Syllabus

Rational and Irrational drug design

Gene organization

Vector design

Gene Delivery and expression system choice

Expression optimization

Confirmation of expression

Analysis of functional properties

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
100 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 The assessment approach for this module will be 100% Continuous Assessment with a range of assessment methods employed including some of the following: short-form assessment exams incl. MCQs, project assignments, practical work, essays, oral presentations, vivas etc. Continuous Assessment UNKNOWN 100 % OnGoing 1,2,3,4,5,6,7,8,9
             
             

Part Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Independent Learning UNKNOWN Self Study 7 Weekly 7.00
Online Lecture Online Lecture 2 Weekly 2.00
Tutorial Online Tutorial 1 Monthly 0.25
Total Part Time Average Weekly Learner Contact Time 2.25 Hours

Module Resources

Non ISBN Literary Resources

Rodney, J.Y., Biotechnology and biopharmaceuticals: Transforming Genes into Drugs, Wiley-Liss, 2003

Brown, T.A., Gene Cloning and DNA Analysis. An Introduction., Oxford Blackwell, 2006

Rick, N.G., Drugs: From Discovery to Approval, Wiley-Liss, 2004

Journal Resources

as per moodle resources

URL Resources

as per moodle resources

Other Resources

NCBI.com

Sciencedirect.com

DNAi.org

Cloud Based Educational Games (CBEG)

genome.ucsc.edu/

 

 

Additional Information

None