BIO08048 2019 RECOMBINANT DRUG DEVELOPMENT AND ENGINEERING

General Details

Full Title
RECOMBINANT DRUG DEVELOPMENT AND ENGINEERING
Transcript Title
RECOMBINANT DRUG DEVELOPMENT A
Code
BIO08048
Attendance
N/A %
Subject Area
BIO - Bio Tech/Eng/Chem
Department
LIFE - Life Sciences
Level
08 - NFQ Level 8
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2019 - Full Academic Year 2019-20
End Term
9999 - The End of Time
Author(s)
Kieran Tobin, Macdara Bodeker, Mary Butler
Programme Membership
SG_SBIOP_E08 201900 Level 8 Certificate in Science in Biopharmaceutical Science SG_SBIOP_E08 201900 Certificate in Science in Bioprocessing Technologies SG_SBIOT_E08 SG_SBIOP_K08 201900 Bachelor of Science (Honours) in Biopharmaceutical Science. SG_SCOLI_E08 201900 Certificate in Science in Colin McLeans Test Programme
Description

The subject aim is to introduce the students to the drug discovery and development process. The subject will compare traditional pharmaceutical drug development to biopharmaceutical drug development. The module will include an in depth study of the different modes and methods of recombinant protein expression in different cellular hosts. The module will introduce the analysis and manipulation of recombinant protein expression in the biopharmaceutical sector.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Differentiate between irrational and rational drug design. Describe the methods of drug target identification and validation.

2.

Outline the molecular methods and components required to characterize, clone and express a gene of interest.

3.

Categorize the essential steps in the design and regulation of a recombinant expression system.

4.

Examine methods of verifying the functional and molecular characteristics of the recombinant protein.

5.

Perform research on a relevant topic and analyse, evaluate and communicate and explain scientific data relating to Recombinant Drug development.

Teaching and Learning Strategies

'This module will be delivered part-time in the form of on line tutorials augmented by independent learning and directed learning. This approach is expected to address student learning needs. Moodle will be used as a repository of educational resources and as a means of assessment (e.g. quizzes, uploading assignments and journals). 

 

Module Assessment Strategies

 

The assessment approach for this module will be 100% Continuous Assessment with a range of assessment methods employed including some of the following: short-form assessment exams incl. MCQ's, project assignments, practical work, essays, oral presentations, vivas etc.

 

The miniproject is a MANDATORY form of assessment for any modules on this programme with a miniproject component.

Repeat Assessments

Repeat Continuous Assessment or Project Resubmission.

Module Dependencies

Prerequisites
Molecular Biology
Co-requisites
None
Incompatibles
None

Indicative Syllabus

Drug Discovery.

Overview of key molecular biological processes and techniques.

Recombinant protein expression.

Recombinant protein analysis, characterization and manipulation.

Recombinant expression experiments in cell lines by different techniques.

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
100 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Continuous Assessment on theory lecture content. Continuous Assessment Multiple Choice 15 % Week 7 2,3,4
2 Continuous Assessment on theory lecture content. Continuous Assessment Multiple Choice 15 % Week 11 1,2,3,4
3 Long Answer Questions Continuous Assessment Closed Book Exam 30 % Week 14 1,2,3,4
4 Essay project Project Essay 35 % End of Term 5
5 oral interview Continuous Assessment Interview 5 % End of Term 5

Part Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Distance Learning Suite Online lectures 2 Weekly 2.00
Independent Learning Not Specified Project work and study 5 Weekly 5.00
Total Part Time Average Weekly Learner Contact Time 2.00 Hours

Module Resources

Non ISBN Literary Resources

Biotechnology and Biopharmaceuticals: Transforming Genes into Drugs.  Author: Rodney, J.Y.Ho. Wiley-Liss 2003

Gene Cloning and DNA Analysis: An Introduction. Author Brown, T.A. Oxford Blackwell 2006

Drugs: From Discovery to Approval. Author: Rick, N.G., Wiley-Liss Press. 2004

Journal Resources

as above

URL Resources

as above

Other Resources

None

Additional Information

The miniproject is a MANDATORY form of assessment for any modules on this programme with a miniproject component.