BIO08037 2014 BIOPHARMACEUTICAL SCIENCE PRACTICAL
This Biopharma laboratory practical module will provide students with practical knowledge, know-how and practical skills associated with biopharmaceutical operations. The relevant learning is achieved through the completion of a sequence of laboratory-based and pilot-plant based practicals and experiments that are designed to impart the required expertise. There will also be some research project work associated with the laboratory practicals.
On completion of this module the learner will/should be able to;
Demonstrate a range of practical know-how and skills associated with relevant, lab-based and pilot-plant based upstream bioprocessing equipment.
Demonstrate a range of practical know-how and skills associated with relevant, lab-based and pilot-plant based downstream bioprocessing equipment.
Perform some defined research project work related to the lab. practicals and interpret and critically evaluate the data and results obtained from this project work.
Take responsibility for and direct the work of other individuals in a quasi-GMP environment.
Demonstrate effective communication skills both orally and in written format.
Teaching and Learning Strategies
Module Assessment Strategies
The assessment strategy will comprise of both observation of skills being acquired as well as formal assessment of knowledge acquisition. There will be a project research element associated with the assessment strategy also.
The miniproject is a MANDATORY form of assessment for any modules on this programme with a miniproject component.
The range of lab-based and pilot-plant based upstream practicals may include some or all of the following items: aseptic techniques; cell culture techniques including cell counting, sub-culturing, thawing up and freezing-down of cells; bioreactor inoculation and operation, sampling and substrate analysis. P ID (Piping and Instrumentation Diagrams) analysis work on bioreactor systems; CIP and SIP cycle operation on bioreactor systems.
The range of lab-based and pilot-plant based downstream practicals covered may include some or all of the following items: filter integrity testing; centrifugation; buffer preparation; chromatography; protein concentration using ultrafiltration; protein concentration and buffer exchange using diafiltration; column packing; theory and practice of industrial-scale chromatography skids.
The range of lab-based and pilot-plant based aseptic processing practicals may include some or all of the following items: contamination control; vial filling; filling line operation; glove integrity testing and environmental monitoring.
Coursework & Assessment Breakdown
|Title||Type||Form||Percent||Week||Learning Outcomes Assessed|
|1||Practical Evaluation Observation assessment of practical skills.||Continuous Assessment||UNKNOWN||20 %||Week 1||1,2|
|2||Open Book Exam Exam at end f day 1 of lab. practicals.||Continuous Assessment||UNKNOWN||20 %||Week 1||1,2,3|
|3||Open Book Exam Exam at end of day 2 of lab. practicals.||Continuous Assessment||UNKNOWN||20 %||Week 1||1,2,3,4|
|4||Project Research project based around the lab. practicals.||Continuous Assessment||UNKNOWN||40 %||Week 14||1,2,3,4,5|
Part Time Mode Workload
|Lecture||Not Specified||Preparatory study material for lab. practicals.||4||Once Per Semester||0.27|
|Laboratory Practical||Science Laboratory||Attendance at laboratory practicals.||16||Once Per Semester||1.07|
|Independent Learning||UNKNOWN||Research project based on lab. practicals.||3||Weekly||3.00|
Walsh, Gary. 'Pharmaceutical Biotechnology'. Wiley. 2007.:-:-#160:::::-:-#160::::
Ratledge, Colin and Kristiansen Bjorn. 'Basic Biotechnology'. Cambridge Press. 2001.
Doran, Pauline M. 'Bioprocess Engineering Principles'. Academic Press. 1995.
Hatti-Kaul, Rajni and Mattiasson, Bo. 'Isolation and Purification of Proteins'. Marcel-Dekker. 2003.:-:-#160::::