BIO08021 2011 RECOMBINANT DRUG DEVELOPMENT AND ENGINEERING

General Details

Full Title
RECOMBINANT DRUG DEVELOPMENT AND ENGINEERING
Transcript Title
RECOMBINANT DRUG ENGINEERING
Code
BIO08021
Attendance
N/A %
Subject Area
BIO - Bio Tech/Eng/Chem
Department
LIFE - Life Sciences
Level
08 - NFQ Level 8
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2011 - Full Academic Year 2011-12
End Term
2014 - Full Academic Year 2014-15
Author(s)
Kieran Tobin, Tony McCabe
Programme Membership
SG_SBIOP_K08 201100 Bachelor of Science (Honours) in Biopharmaceutical Science. SG_SBIOP_E08 201100 Level 8 Certificate in Science in Biopharmaceutical Science SG_SBIOP_E08 201100 Level 8 Certificate in Science in Biopharmaceutical Science SG_SBIOP_E08 201100 Level 8 Certificate in Science in Biopharmaceutical Science SG_SBIOT_E08 201500 Certificate in Science in Bioprocessing Technologies SG_SBIOT_E08
Description

The subject aim is to introduce the students to the drug discovery and development process. The subject will compare traditional pharmaceutical drug development to biopharmaceutical drug development. The module will include an in depth study of the different modes and methods of recombinant protein expression in different cellular hosts. The module will introduce the analysis and manipulation of recombinant protein expression in the biopharmaceutical sector.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Differentiate between irrational and rational drug design. Describe the methods of drug target identification and validation.

2.

Outline the molecular methods and components required to characterize and clone the gene of interest.

3.

Categorize the essential steps in the design and regulation of a recombinant expression system.

4.

Describe methods employed to optimize nucleic acid sequence and cell expression systems for maximum protein expression including methods to optimize the molecular characteristics of purified proteins

5.

Examine methods of verifying the functional and molecular characteristics of the recombinant protein.

6.

Illustrate methods of production of humanized monoclonal antibodies and phage display libraries.

7.

Perform analysis of a recombinant protein

Module Dependencies

Prerequisites
Molecular Biology
Co-requisites
None
Incompatibles
None

Indicative Syllabus

Drug Discovery.

Overview of key molecular biological processes and techniques.

Recombinant protein expression.

Recombinant protein analysis, characterization and manipulation.

Recombinant expression experiments in cell lines by different techniques.

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
70 %
End of Semester / Year Formal Exam
30 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Continuous Assessment Short questions on theory lecture content. Continuous Assessment UNKNOWN 15 % Week 4 1,2,3,4
2 Practical Evaluation Short questions on experimental data Continuous Assessment UNKNOWN 15 % Week 8 7
3 Individual Project Literature project Continuous Assessment UNKNOWN 40 % OnGoing 2,3,4,5,6

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Essay Theory exam Final Exam UNKNOWN 30 % End of Term 1,2,3,4,5,6,7
             
             

Part Time Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Distance Learning Suite Online lectures 2 Weekly 2.00
Independent Learning Not Specified Project work and study 5.5 Weekly 5.50
Total Part Time Average Weekly Learner Contact Time 2.00 Hours

Module Resources

Non ISBN Literary Resources

Biotechnology and Biopharmaceuticals: Transforming Genes into Drugs.  Author: Rodney, J.Y.Ho. Wiley-Liss 2003

Gene Cloning and DNA Analysis: An Introduction. Author Brown, T.A. Oxford Blackwell 2006

Drugs: From Discovery to Approval. Author: Rick, N.G., Wiley-Liss Press. 2004

Other Resources

None

Additional Information

None