BIO06011 2011 Upstream Bioprocessing Level 6.

General Details

Full Title
Upstream Bioprocessing Level 6.
Transcript Title
Upstream Bioproc Level 6.
N/A %
Subject Area
BIO - Bio Tech/Eng/Chem
ASCI - Applied Sciences
06 - NFQ Level 6
10 - 10 Credits
Start Term
2011 - Full Academic Year 2011-12
End Term
2019 - Full Academic Year 2019-20
Kieran Tobin
Programme Membership
SG_SBIOO_E06 201100 Certificate in Science in Biopharma Operations. SG_SGOOD_C06 201600 Higher Certificate in Science in Good Manuf Practive & Technol

This module aims to provide the student with a fundamental understanding of both the theory and practical aspects of cell culture processing as it pertains  to the manufacture of modern biopharmaceutical products.    

Learning Outcomes

On completion of this module the learner will/should be able to;


Describe the basics of cell biology and the process kinetics relating to cell growth and protein expression.  


Explain the different types and formulations of media available. 


Explain cell counting techniques utilising appropriate technology to verify cell density performance during bioreactor operation.   


Describe the various bioreactor designs available and their key features.  


Outline the main operating and control loops for a modern bioreactor and its critical control paramenters.


Perform a range of practical laboratory experiments relating to cell culture processing.

Module Assessment Strategies

A combination of continuous assessment strategies, some laboratory experiments and an end-of-term exam.

Indicative Syllabus

The following is an indicative summary of the main topics included in this module:

Overview of Cell Biology relating to Cell Culture Processing.  

Kinetics of Cell Growth, cell counting techniques, cell density and cell viability measurements.

Cell Culture Media Design and Formulation.

Cell culture scale-up techniques.

Bioreactor Design Features. 

Bioreactor Operation and Control of critical parameters.   

Laboratory practicals associated with cell culture processing.

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
70 %
End of Semester / Year Formal Exam
30 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Continuous Assessment Short-form exams/quizzes and lab. practical write-ups. Continuous Assessment UNKNOWN 70 % OnGoing 1,2,3,4,5,6

End of Semester / Year Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 Final Exam Final Exam UNKNOWN 30 % End of Term 1,2,3,4,5

Part Time Mode Workload

Type Location Description Hours Frequency Avg Workload
Lecture Distance Learning Suite Online lecture. 1 Weekly 1.00
Laboratory Practical Science Laboratory Lab. practical experiments. 20 Once Per Semester 1.33
Directed Learning Not Specified Directed self-study. 5 Weekly 5.00
Total Part Time Average Weekly Learner Contact Time 7.33 Hours

Module Resources

Non ISBN Literary Resources

‘Pharmaceutical Biotechnology - Concepts and Applications' by Gary Walsh.

Wiley Publications.  2007.  ISBN - 978-0-470-01244-4.

‘Basic Biotechnology' by Colin Ratledge and Bjorn Kristiansen.

Cambridge Press. 2001.  ISBN - 0-521-779170.

Other Resources


Additional Information